Ebook Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

Ebook Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

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Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

Ebook Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

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From the Back Cover

Central nervous system (CNS) drugs are a leading pharmaceutical area, since many CNS diseases remain untreated or without optimum drugs. Unfortunately, the blood-brain barrier (BBB) restricts access of drug molecules circulating in the blood stream to penetrate into the brain cells – and that is where this important book steps in. With practical and proven solutions for CNS drug discovery efforts, this book educates drug researchers about the BBB so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. The chapters are written by world-class scientists actively engaged in CNS research from both academia and industry, applying this to more quickly discover and develop better drugs. Among the topics they review are state-of-the-art in silico, in vitro, and in vivo tools for assessing the BBB and advanced delivery technologies. Coverage includes fundamental knowledge about the BBB, implications of these restrictions on free drug exposure at the target in brain, pharmacokinetics (PK) and pharmacodynamics (PD) relationships (PK/PD), physiologically-based pharmacokinetic (PBPK) brain models, medicinal chemistry design principles, and case studies from successful CNS drug discovery. These case studies examine how the integration of data and design strategies advanced successful new drugs to market. A unique and valuable reference resource for practicing medicinal chemists, this book: • Focuses on practical solutions of brain exposure problems faced by drug researchers • Helps readers understand, control and measure the exposure of the drug candidates to the CNS • Covers BBB physiology; medicinal chemistry design principles; free drug hypothesis for the BBB; and transport mechanisms including passive diffusion, uptake/efflux transporters and receptor-mediated processes • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

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About the Author

Li Di is an associate research fellow in the Pharmacokinetics, Dynamics, and Drug Metabolism Department at Pfizer Global Research and Development and has extensive experience in the pharmaceutical industry. She has over 100 publications, presented over 70 invited lectures, and teaches an American Chemical Society short course on drug-like properties. Edward Kerns worked in pharmaceutical research and development for over 30 years, was associate director at Wyeth and Bristol-Myers Squibb, then was at the NIH-National Center for Advancing Translational Sciences. He published over 90 journal papers or book chapters and 3 books, and teaches an American Chemical Society short course on drug-like properties.

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Product details

Hardcover: 600 pages

Publisher: Wiley; 1 edition (February 2, 2015)

Language: English

ISBN-10: 1118788354

ISBN-13: 978-1118788356

Product Dimensions:

6.3 x 1.4 x 9.2 inches

Shipping Weight: 2 pounds (View shipping rates and policies)

Average Customer Review:

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Amazon Best Sellers Rank:

#899,225 in Books (See Top 100 in Books)

Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs PDF
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Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs PDF

Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs PDF

Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs PDF

Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs PDF

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Get Free Ebook The Story of Christianity: A Chronicle of Christian Civilization From Ancient Rome to Today, by Jean-Pierre Isbouts

Get Free Ebook The Story of Christianity: A Chronicle of Christian Civilization From Ancient Rome to Today, by Jean-Pierre Isbouts

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The Story of Christianity: A Chronicle of Christian Civilization From Ancient Rome to Today, by Jean-Pierre Isbouts

Get Free Ebook The Story of Christianity: A Chronicle of Christian Civilization From Ancient Rome to Today, by Jean-Pierre Isbouts

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About the Author

JEAN-PIERRE ISBOUTS is the author of National Geographic's best-selling books, Who's Who in the Bible, The Biblical World, and In the Footsteps of Jesus. ISBOUTS is a recognized expert in the cultural and archaeological history of the Bible and speaks frequently to groups ranging from academic audiences to large church gatherings and Middle East tours. He is the director of Charlton Heston's Voyage Through the Bible and is a professor at Fielding University in Santa Barbara, CA.

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Product details

Hardcover: 368 pages

Publisher: National Geographic (October 28, 2014)

Language: English

ISBN-10: 1426213875

ISBN-13: 978-1426213878

Product Dimensions:

9.5 x 1.1 x 11.2 inches

Shipping Weight: 3.6 pounds (View shipping rates and policies)

Average Customer Review:

4.8 out of 5 stars

22 customer reviews

Amazon Best Sellers Rank:

#330,964 in Books (See Top 100 in Books)

This book is simply stunning! The color and layout are beautiful. The content is also very well organized and thoughtfully conveyed. I really appreciate the oberall level of detail.

The quiet elegance of this exquisite presentation embraces the subject with a discerning scholarship only this author possesses.

Got this for research. Was in very good condition. Very happy.

Good

Beautiful pictures! And the book was in excellent condition.

Beautiful book. Great read!

Great elements of history thrown into this book. Picked it up for a class I'm taking, but plan to hold onto this one for a long time. I'm not extremely religious, but I do find historically interesting. Great as a gift for anyone who strongly appreciates history/christianity. It's full of wonderful illustrations, and pieces of art.

Great

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Free Download How to Be a Woman

Free Download How to Be a Woman

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Audible Audiobook

Listening Length: 8 hours and 45 minutes

Program Type: Audiobook

Version: Unabridged

Publisher: HarperAudio

Audible.com Release Date: September 25, 2012

Whispersync for Voice: Ready

Language: English, English

ASIN: B009GBXLBO

Amazon Best Sellers Rank:

How to Be a Woman, by Caitlin MoranI’m a feminist, a strident feminist and a male. I have been for a long time. In 1965 I fought against women’s hours, which required college women to be in their dorms by 11:00 p.m. at Indiana University, while men were allowed to roam free all night. I’ve been married to a strident feminist since 1967, and recommend that path to anyone. So I’m reasonably well versed in feminist culture over the years.How to Be a Woman, by Caitlin Moran, is, hands down, the best source on feminism I’ve ever encountered. It surely helps that it is hilarious. It also helps that at least half the barbs are directed at herself, and most of the rest at other women. (Actually, she lets men off pretty easy.) She is shockingly frank about all sorts of socially unacceptable conduct in which she has engaged, such as binge drinking, drug use and promiscuity. But shining through is a deep understanding of things that women routinely experience from puberty through early middle age, and how to live and grow through them. Again and again she raises up values I value.To make it appropriate to all genders, I would restate her best known quote as: Feminism is believing that if you have a vagina you should be in charge of it.Her championing of guilt-free abortion is radical, finding it just as appropriate as deciding to bear a child. "By whatever rationale you use, ending a pregnancy 12 weeks into gestation is incalculably more moral than bringing an unwanted child into this world." She quotes a like minded friend: “It’s one of the top four best things I ever did—after marrying my husband, having my son, and getting a fixed quote on the loft conversion.”The trauma of her first pubic hairs resonates, I assure my female friends, quite fully with me as a male.I’m not sure quite how old young people should be before reading this book. It does unabashedly relate experiences that will make parents (and grandparents, teachers, etc.) cringe. But I’m not sure that it makes those experiences attractive, and much of what I know of those from 15 to 25 makes me think their culture normalizes such tales so universally that this book only puts them in a real world context that is OK with me. Such stories will be surely old hat to the bulk of college sophomores, and probably to many a high schooler, and too many in middle school.I’m not sure quite how liberated adults should be before reading this book. I surely have friends who will be shocked that I would recommend such trash. But I do. One person’s trash is another’s treasure. This book is a rare treasure.

"So here is the quick way of working out if you're a feminist. Put your hand in your pants.a) Do you have a vagina? andb) Do you want to be in charge of it?If you said 'yes' to both, then congratulations! You're a feminist.”I read this book as part of a feminist reading club on Goodreads. I had never really thought about being a feminist before. In fact, a feminist to me sounded like one of those red-faced, angry women protesting about something or the other, and always bitching about men. But guess what, being a feminist is about understanding yourself as a woman and defining the role you want to play for yourself in your own life. It's about taking control, it's about asserting our freedoms, and it's about celebrating our interactions with men in a way that is satisfying and fulfilling for both.Caitlin Moran tells her story in a relatable, humorous, and often irreverent style that did make me stop and think about many issues. Some of her life choices may be questionable, especially in the culture I was raised in, but hey, that's exactly the point. She can --and should-- choose what she believes is right for herself. In the end, I found her courageous for speaking things many of us will shy away from, and to find humor in it too.

As a 50 year old woman I can look back on my life and see how this book would have been VERY useful to read at age 15. It does not matter if your life is parallel to Ms. Moran's - or not. Actually, that's the point. For once we have a brave woman who is putting her experience out there for the world to see (and laugh about). I applaud her. Anyone who condemns her, condemns her because they are not as brave, honest or true to themselves. As women we have been dictated on how to behave by mostly religious and political members - that have been predominantly men. We need to unapologetically break the glass ceiling and feel the cool wind of change upon our faces. Ms. Moran reminiscences about the confusion of being an adolescent woman through humor, intelligence and tact. It is a journey I thoroughly enjoyed.

"When the subject turns to abortion, cosmetic intervention, birth, motherhood, sex, love, work, misogyny, fear, or just how you feel in your own skin, women still often won't tell the truth to each other unless they are very, very drunk."Caitlin Moran is right. Nowadays, you DO have to be drunk. The last time I heard a female friend relate anything even remotely personal was when L. had too much wine at book club and really tore into her deadbeat ex-husband. (Seriously, you earn $98,000 a year but can't pay child support? You JERK!)older women who were returning to finish degrees that had been nudged aside for marriage and family. Those broads rocked my world and led me away from the path of righteousness, and I THANK THEM every day for doing so. Thirty years have slipped by, and I've yet to find another group of women to whom I can say ANYTHING and not be judged. And, man, do I ever miss that! Now, if you talk about S-E-X, it's deemed T-M-I. Why is wanting to talk about something we all do too much information? Why does no one wants to go there?Well, Ms. Moran GOES THERE. From pubic hair (Yes!) to high heels (No!), she lets it all hang out. And what fun it was spending time with her. Though a continent and more than a decade separate us, I may possibly have more in common w/ Moran than any woman I've met in real life. I found her let-your-freak-flag-fly message to be reassuring, entertaining and pants-wettingly funny. Not everyone will like her, or her book. And that's okay. If even thinking about the f-word makes you blush, if you've never concocted an imaginary relationship with a male celebrity, or if you've never touched yourself "down there," put the book down and back away.If you're like me, you'll love it.Being a woman . . . after all these years, I'm pretty sure I've been doing it right.

How to Be a Woman PDF
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How to Be a Woman PDF

How to Be a Woman PDF

How to Be a Woman PDF

How to Be a Woman PDF

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